Table 2.
Characteristics of the Patients with Germ Cell Tumors and Results of Immunohistochemistry for AFP and GATA-4
| Patient | Tumor | Immunohisto- chemistry | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No. | Age at diagnosis (years) and sex | Outcome (years after diagnosis) | Localization | Other | Histology | Necrosis/hemorrhage (% of total tumor tissue) | Serum-AFP (mg/L) | AFP GATA-4 positivity (% of viable tumor tissue) | |
| 1 | 11 F | NED (1) | Vagina | EC | 85 /5 | 25,500 | 0 | 0 | |
| 2 | 2.5 F | NED (7) | Pelvis | YST | 5 /5 | 92,700 | 30 | 90 | |
| 3 | 1.3 M | Died (5) | Pelvis | Lung met. | YST | 5 /10 | 48,500 | 0 | 10 |
| 4 | 1.6 M | NED (8) | Pelvis | YST | − /− | 53,200 | 5 | 80 | |
| 5 | 1.0 M | NED (7) | Testis | YST | − /− | 430 | 1–2 | 5 | |
| 6 | 14.5 F | NED (14) | Ovary | Omn. met. | YST | 90 /− | <25 | 1–2 | 5 |
| 7 | 1.5 F | NED (2) | Pelvis | YST | <5 /10 | 16,500 | 1–2 | 0 | |
| 8 | 1.6 F | NED (16) | Pelvis | YST | <5 /− | 9,300 | 15 | 95 | |
| 9 | 2.1 F | NED (1) | Pelvis | Lung met. | YST | 50 /− | 19,954 | 5 | 40 |
| 10 | 4.0 M | NED (2) | Testis | YST | <5 /− | 2,173 | 1–2 | 10 |
NED, no evidence of disease; Lung met., lung metastasis; Omn. met., omentum metastasis; EC, embryonal carcinoma; YST, yolk sac tumor.