Figure 6.

There is a higher proliferation of purified tumor B cells in case 8 with t(11;18) as compared with case 6 (no translocation) or normal memory B cells without any stimuli after 3 days of cell culture (A). Data are expressed as mean of triplicate [³H]thymidine cpm uptake values, with SD as an error bar. The different proliferation in each case was paralleled by the survival rate as determined by trypan blue staining and lowest in normal memory B cells and case 6 and highest in case 8 after 7 days of cell culture without any stimuli (B, open bars). However, these differences disappeared by triggering with anti-CD40 (B, closed bars) and resulted in increased survival of tumor and normal B cells.