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. 1999 Nov;155(5):1773–1779. doi: 10.1016/S0002-9440(10)65493-4

Figure 4.

Figure 4.

Depletion of CD4 but not CD8 T cell subsets ablate the production of serum anti-fluorescein IgG after intratracheal FITC. Mice were treated with GK1.5 (anti CD4) or 2.43 (anti-CD8) monoclonal antibodies 2 days before and at intervals after a single dose of intratracheal FITC or PBS in Balb-c mice. Mice were killed at day 21 and serum was assayed for fluorescein-specific antibodies. Increased production of serum anti-fluorescein IgG was noted in FITC-treated mice. This production was ablated in CD4-depleted but not CD8-depleted mice. *P < 0.05 compared to PBS treated mice, ANOVA; #P < 0.05 compared to FITC-treated mice with normal T cell subsets, ANOVA; n = 5–8 animals; representative data from three experiments.