Figure 5.

Depletion of T cell subsets does not alter lung hydroxyproline content after intratracheal FITC. Mice were treated with GK1.5 (anti CD4) or 2.43 (anti-CD8) monoclonal antibodies 2 days before and at intervals after a single dose of intratracheal FITC in Balb-c mice. Mice were killed at day 21 and lungs were assayed for hydroxyproline content. Depletion of either CD4 or CD8 T cell subsets did not alter the increase in lung hydroxyproline content after intratracheal FITC. *P < 0.05 compared to PBS-treated mice, ANOVA; ^#P not significant compared to FITC-treated mice with normal T cell subsets, ANOVA; n = 18 to 30 animals, pooled data from three identical experiments.