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SCID mice do not develop anti-fluorescein IgG after intratracheal FITC. Balb-c SCID or normal Balb-c mice were treated with a single dose of intratracheal FITC or PBS. Mice were killed at day 21 and serum was assayed for fluorescein-specific antibodies. Increased production of serum anti-fluorescein IgG was noted in normal Balb-c mice but not SCID mice. *P < 0.05 compared to PBS-treated Balb-c mice, ANOVA; #P < 0.05; compared to FITC-treated Balb-c mice, ANOVA; n = 5–8 animals.
