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RAG-KO mice do not develop anti-fluorescein IgG after intratracheal FITC. RAG-KO or normal C57BL-6 mice were treated with a single dose of intratracheal FITC or PBS. Mice were killed at day 21 and serum was assayed for fluorescein-specific antibodies. Increased production of serum anti-fluorescein IgG was noted in normal C57BL-6 mice but not in RAG-KO mice. *P < 0.05 compared to PBS-treated C57BL-6 mice, ANOVA; #P < 0.05 compared to FITC-treated C57BL-6 mice, ANOVA; n = 5–8 animals.
