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Hypotheses about the Pathogenesis of Mixed Thyroid Tumors
| Hypothesis | Expected results from the two components | |
|---|---|---|
| Clonality assay | LOH/mutation assay | |
| “Stem cell” theory | Same clonality | Same (similar) pattern |
| “Divergent differentiation” | Same clonality | Different (similar) pattern |
| “Field effect” | Different clonality | Different pattern |
| “Collision effect” | Different clonality | Different pattern |
| “Hostage” theory | Different clonality | Different pattern |
