Table 3.

Transmission Electron Microscopy Features

Structures	Normal skin	Non-pressure-treated regions	Pressure-treated regions
Dermal epidermal junction
keratinocyte microfoot	typical organization	almost absent	increase of depth
lamina lucida	well formed	not well defined	well formed
lamina densa	well formed	thickened	well formed
hemi-desmosomes	typical organization	disturbed organization	typical organization
anchoring fibrils	regularly distributed	irregularly distributed and thickened	regularly distributed
Elastic system fibers	well organized	well organized	well organized
Collagen bundles	typical organization	large, with thick fibers	signs of degradation
Microvessels	patent	frequently occluded	frequently occluded
Myofibroblasts	absent	present	signs of apoptosis