Figure 6.
Schematic representation of Cu/ZnSOD and glutathione antioxidant pathways and putative interactions with PrP and copper. GR and Cu/ZnSOD activity are both reduced in PrP−/− neurons. ONOO− and OH· can damage GR and hence lower its activity (as indicated by dashed arrows). Pathways involving possible interactions with copper have been bolded. Cu/ZnSOD, copper/zinc superoxide dismutase; GR, glutathione reductase; GPx, glutathione peroxidase; H2O2, hydrogen peroxide; OH·, hydroxyl radical; ONOO−, peroxynitrite; O2−, superoxide radical.