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A and B: In situ nick end labeling (ISNEL) of the lung from a wild-type (A) and p53 knockout (B) mouse at 24 hours after the treatment. Many ISNEL-positive cells were observed among the bronchial epithelial and alveolar cells in both groups. Original magnification, ×400. C: ISNEL index in the bronchi (top), alveoli (second panel), small intestinal crypts (third panel), and villi (bottom). Solid line, wild-type mice; dashed line, p53 knockout mice.
