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Chronic high-titer coxsackievirus infection in B-cell-deficient mice. C57BL/6 and BcKO mice were infected with CVB3. At the indicated time points, 2 mice were bled, sacrificed, and perfused with saline. Serum and tissues were titered; mean titers are shown for 2 mice per strain at each time point. All titers are shown as pfu/gram, except for serum (pfu/ml). Open symbols, C57BL/6 mice; solid symbols, BcKO mice.
