Figure 3.

Estrogen increased wound collagen deposition and increased wound strength at day 80. A: Hydroxyproline levels were increased significantly in day 7 wound tissue by estrogen treatment for both males and females. At day 80 the difference between placebo and estrogen was only significant in females. *P < 0.05; n = 5 per group (d7) and n = 4 per group (d80). B: Mechanical properties of day 80 wounds assessed by the DAS showed an increase in wound stiffness at day 80 in the estrogen-treated wounds, which was significant only in females. *P < 0.05, n = 4 per group.