Figure 4.

Cellular localization of IL-18, ICE, IL-1RI, IFN-γRα, IFN-γRβ, uPAR, and ICAM-1 in the rat liver regenerating by recruitment of oval cells. Paraffin sections from rat liver at day 7 after partial hepatectomy in the AAF/PHx protocol were (A) stained with H&E to demonstrate the histological features; or immunostained using the peroxidase method with diaminobenzidine as detection substrate and antibodies against IL-18 (B); ICE (C); IL-1RI (D); IFN-γRα (E); IFN-γRβ (F); uPAR (G); and ICAM-1 (H). Original magnification for all sections, ×400. Portal areas with strongly stained ductular structures of oval cells extending into the liver parenchyma are shown.