Table 1.

Summary of Genes and Gene Products

Gene products identified by suppression subtractive hybridization and Northern blot analysis
Gene name/alternative name	Remarks	References
Interferon-γ receptor α (IFN-γRα)	Exhibits ligand binding properties towards IFN-γ.	30
gp91phox	Heavy chain of cytochrome b558. Gp91 phox is induced as a primary response gene by IFN-γ.	31
Interleukin-1β (IL-1β)	IL-1β binds to IL-1RI and induces transcription and translation of IFN-γ in hepatocytes.	17
Lymphocyte function-associated molecule 1-α (LFA-1) β2αL integrin; CD18, αL subunit; CD11a	LFA-1 is regulated in response to IFN-γ. Binds ICAM-1 and ICAM-2, which are induced as secondary response genes by IFN-γ.	32
Eukaryotic initiation factor-2-associated 67-kd protein	Protects eIF-2 from inhibitory phosphorylation by IFN-γ induced eIF-2 kinases.	33, 34
α-fetoprotein	Suppresses IFN-γ production.	35

Genes studied by Northern blot analysis and/or immunohistochemistry
Gene name/alternative name	Remarks	References
Interferon-γ (IFN-γ)	High-affinity ligand of IFN-γRα.	20
Interleukin-18 (IL-18); Interferon gamma-inducing factor (IGIF)	Induces IFN-γ production.	16
Interleukin-1β converting enzyme (ICE) caspase-1	ICE is induced as a secondary response gene by IFN-γ. ICE is involved in the activation of IL-1β and IL-18.	19, 36
IFN-γ receptor β (IFN-γRβ)	β-chain of the IFN-γ receptor complex, involved primarily in signaling.	20
Urokinase-type plasminogen activator receptor (uPAR)	uPAR is induced by IFN-γ as a secondary response gene.	37
Urokinase-type plasminogen activator (uPA)	uPA is induced by IFN-γ.	37
Intercellular adhesion molecule-1 (ICAM-1); CD54	ICAM-1 is induced as a secondary response gene by IFN-γ, binds to LFA-1.	20