Table 3.

Histology of Acute EAE in SJL Mice Sensitized at Different Ages

Age (wks) at sensitization	Day of sampling	Clinical grade	Inflammation	Demye- lination
2	7	0	++	++
3	7	0.5	++	+
4	7	0	+	−
6	7	1.0	+	+
8	7	1.0	+/−	+
10	7	2.0	++	+

++++, Total white matter involvement; +++, formation of plaques, fusion of areas of demyelination and inflammation; ++, perivascular and involvement of white matter; +, perivascular; +/−, little white matter involvement.