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Electron micrographs of apical parts of proximal tubular cells from megalin-deficient (A) and control mice (B). Cells from megalin −/− mice exhibit a significant reduction of the endocytic apparatus including coated pits (arrows), endosomes (E), and dense apical tubules (arrowheads). The brush border (BB) and mitochondria (M) appear normal. The inset highlights a coated pit (CP) in the wild-type kidney section. G, Golgi apparatus; L, lysosome. A and B, ×20,000; inset, ×47,000.
