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Type 1 IGF-R immunohistochemistry on frozen sections of PCa in prostate and bone marrow metastases. Frozen sections were stained with a monoclonal mouse anti-human type 1 IGF-R. A and B: Low and high power of nonneoplastic prostate. C and D, Low and high power of primary PCa. E and F: metastatic androgen-independent PCa in bone marrow biopsies from two patients. Original magnifications, A, ×100; B, ×200; C, ×200; D–E, ×400.
