Table 2.
Analysis of Correlation between PTEN Immunostaining and PTEN Intragenic LOH in Cases with Decreased Immunostaining and Apparently Discordant Tumors
| Tumor | Immuno-staining score | PTEN | |||||
|---|---|---|---|---|---|---|---|
| 10q22-23 Markers | |||||||
| S1765 | S2491 | AFM086 | S2492 | IVS8 | S541 | ||
| 41 | ++ | LOH | NI | LOH | ROH | ROH | NI |
| 52 | ++ | LOH | NI | ROH | ROH | N/A | ROH |
| 53 | ++ | LOH | ROH | ROH | ROH | ROH | LOH |
| 50 | ++ | LOH | ROH | ROH | NI | ROH | NI |
| 40 | + | LOH | N/A | NI | N/A | LOH | ROH |
| 59 | + | LOH | N/A | LOH | N/A | LOH | ROH |
| 66 | + | ROH | NI | LOH | N/A | N/A | LOH |
| 57 | + | ROH | LOH | LOH | N/A | N/A | ROH |
| 55 | + | ROH | NI | NI | N/A | LOH | LOH |
| 45 | + | ROH | NI | ROH | NI | ROH | ROH |
Tumor numbers correspond to those of Feilotter et al. 13
LOH, loss of heterozygosity; ROH, retention of heterozygosity; NI, not informative (germline homozygosity at marker); N/A, not applicable or not done.