Figure 1.

Expression of Cox-1 and Cox-2 in normal arterial and atherosclerotic plaque tissue. Frozen sections of nonatherosclerotic human arteries and atheromatous plaques were stained for Cox-1 and Cox-2 employing horseradish-peroxidase-mediated immunohistochemistry (red reaction product). No immunoreactivity was observed in tissue stained with the respective control IgG1 antibody (control). The lumen of the artery is at the top of each photomicrograph. Analysis of five normal aortic tissue and seven atheroma obtained from different donors showed similar results.