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Increasing RAI frequency with higher stage of disease. Stage I thymomas showed the lowest RAI frequency values with mean of 4.1% and SD of 4.2%. Increasing RAI values were observed in later stages: stage II, 8 ± 4.7%; stage III, 16 ± 14.8%; and stage IV, 15.2 ± 10%. However, only the RAI frequency difference between stages I and IV was statistically significant (Mann-Whitney U test, P = 0.027).
