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Expression of Lptn and of the Lptn receptor GPR-5 by in vitro-stimulated T cells. By quantitative real-time RT-PCR both Lptn (A) and the Lptn receptor GPR-5 (B) were found to be up-regulated on stimulation with ConA and PMA in CD3+ T cells isolated from peripheral blood. Addition of the immunosuppressive-acting drugs cyclosporine A (CyA), FK506, and dexamethasone (Dexa) prevented the up-regulation of Lptn and Lptn receptor GPR-5 by PMA in a similar manner.
