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. 2001 Nov;159(5):1895–1904. doi: 10.1016/S0002-9440(10)63036-2

Figure 3.

Figure 3.

Diminution of renal lesions (a), TGF-β (b), and matrix (c) mRNA expression in AT1(−/−) with severe overload nephropathy. Morphological lesions (at day 7: 8.3 ± 2.1 versus 9.0 ± 1.0, n = 5, P = 0.63; at day 14: 5.6 ± 0.5 versus 9.6 ± 1.5, n = 5, *P < 0.01) (a) and TGF-β mRNA expression (at day 7: 3.9 ± 2.1-fold versus 4.3 ± 1.5-fold increase, n = 3, P = 0.84; at day 14: 2.1 ± 0.8 versus 3.9 ± 0.5, n = 4, **P < 0.05) (b) were significantly attenuated in AT1(−/−) with severe overload nephropathy at day 14, whereas FN mRNA expression was diminished during the whole disease course (at day 7: 1.3 ± 0.7 versus 5.3 ± 2.2, n = 4, **P < 0.05; at day 14: 3.2 ± 0.7 versus 6.8 ± 1.1, n = 3, *P < 0.01) (c).