Table 1.

Systemic and Renal Functional Parameters in Control Rats and Rats with Accelerated PHN

	Controls 4 months	PHN 4 months	Controls 8 months	PHN 8 months	PHN + Lisinopril	PHN + Lacidipine
Systolic blood pressure, mmHg	119± 7	143± 28	130± 4	160 ± 13*	110± 19†	100± 6†
Proteinuria, mg/day	32 (28–42)	663* (658–665)	47 (37–56)	742* (664–875)	155*† (63–707)	831.4* (807.3–860.1)
Serum creatinine, mg/dl	0.7 (0.7–0.8)	1.0 (0.9–1.1)	0.8 (0.7–0.8)	1.4* (1.2–1.5)	0.9 (0.8–1.4)	1.3 (1.1–1.6)
Glomeruli with sclerosis, %	0.5 (0–1)	35* (24–54.5)	4 (3.5–4.5)	65* (55–74)	9† (6.0–52.0)	80* (71–89)
Interstitial damage, score	0 (0–0)	2.0* (1.5–2.0)	0 (0–0.5)	2.5* (2.0–3.0)	1.0† (0–2.0)	2.0* (2.0–3.0)
Tubular damage, score	0 (0–0.5)	2.0 (1.5–2.0)	1.0 (1.0–1.0)	2.9* (2.4–3.0)	1.0† (0–3.0)	2.0* (2.0–3.0)

All data are expressed as median and interquartile range except the blood pressure (mean ± SD).

*P < 0.05 versus controls at corresponding time.

^†P < 0.05 versus PHN 8 months.