Figure 1.

TRANCE/RANKL KO and Ctl mice with serum transfer arthritis develop inflammation that is clinically and histologically similar. TRANCE/RANKL KO (KO) and Ctl mice were injected with K/B×N serum or PBS (experiments C and D only) and sacrificed at 12 to 13 days (experiments A and B) or 21 days (experiments C to E) after the initial serum injection. Arthritis was monitored by clinical index (A) and measurement of ankle thickness, represented as ankle thickening (B) and AUC(0-12)AT and MaxAT (C). Histopathological scoring of inflammation in H&E-stained sections (D) was performed as outlined in Table 1 ▶ .