Table 4. .

CNV of C4 and RCCX Modules among European American Female and Male Controls (FC and MC, respectively), Female and Male First-Degree Relatives (FF and MF, respectively), Female Patients with SLE from Ohio Study (FP), and Female Patients with SLE from a Replication Study (SP)

	FC		MC		FF		MF		FP		SP
Genes or Haplotypes and Group	No.	Frequency	No.	Frequency	No.	Frequency	No.	Frequency	No.	Frequency	No.	Frequency
Total C4 genes:
2	6	.015	1	.008	14	.063	10	.07	20	.093	3	.025
3	105	.27	30	.234	68	.308	48	.338	71	.329	45	.381
4	231	.594	81	.633	120	.543	71	.5	112	.519	62	.525
5	41	.105	12	.094	15	.068	13	.092	11	.051	4	.034
⩾6	6	.015	4	.031	4	.018	0	0	2	.009	4	.033
Total	389	…	128	…	221	…	142	…	216	…	118	…
C4A genes:
0	5	.013	0	0	6	.027	6	.043	14	.065	3	.025
1	70	.182	19	.148	53	.241	37	.262	57	.264	39	.331
2	218	.566	71	.555	121	.55	77	.546	112	.519	63	.534
3	81	.21	30	.234	32	.145	20	.142	24	.111	11	.093
4	9	.023	8	.063	8	.036	1	.007	8	.037	1	.008
5	2	.005	0	0	0	0	0	0	1	.005	1	.008
Total	385	…	128	…	220	…	141	…	216	…	118	…
C4B genes:
0	9	.023	5	.039	5	.023	5	.035	6	.028	3	.025
1	99	.257	39	.305	52	.236	27	.191	49	.227	16	.136
2	250	.649	75	.586	158	.718	102	.723	153	.708	90	.763
3	26	.068	9	.07	4	.018	7	.05	7	.032	6	.051
⩾4	1	.003	0	0	1	.005	0	0	1	.005	3	.025
Total	385	…	128	…	220	…	141	…	216	…	118	…
Long C4 genes:
0	4	.01	0	0	5	.023	3	.021	10	.046	0	0
1	26	.067	5	.039	18	.082	18	.127	20	.093	9	.101
2	100	.257	29	.227	60	.273	37	.261	63	.292	30	.337
3	145	.373	46	.359	78	.355	58	.408	68	.315	30	.337
4	98	.252	44	.344	53	.241	22	.155	51	.236	17	.191
5	14	.036	3	.023	5	.023	4	.028	3	.014	2	.022
6	2	.005	1	.008	1	.005	0	0	1	.005	1	.011
Total	389	…	128	…	220	…	142	…	216	…	89a	…
Short C4 genes:
0	130	.334	51	.398	64	.291	35	.246	70	.324	20	.225
1	170	.437	59	.461	109	.495	69	.486	96	.444	47	.528
2	80	.206	11	.086	42	.191	36	.254	43	.199	19	.213
3	8	.021	7	.055	4	.018	2	.014	6	.028	1	.011
4	1	.003	0	0	1	.005	0	0	1	.005	2	.022
Total	389	…	128	…	220	…	142	…	216	…	89a	…
RCCX haplotypes:
L	33	.042	14	.055	31	.07	21	.074	32	.074	5	.028
S	88	.113	20	.078	55	.125	43	.151	73	.169	28	.157
LL	387	.497	139	.543	205	.466	117	.412	199	.461	76	.427
LS	208	.267	60	.234	123	.28	85	.299	105	.243	54	.303
SS	1	.001	0	0	1	.002	1	.004	4	.009	0	0
LSL	11	.014	3	.012	7	.016	5	.018	6	.014	2	.011
LSS	25	.032	8	.031	7	.016	6	.021	5	.012	6	.034
LLL	24	.031	11	.043	10	.023	6	.021	7	.016	6	.034
SSS	0	0	1	.004	0	0	0	0	0	0	0	0
LSSS	0	0	0	0	1	.002	0	0	1	.002	0	0
LLLL	1	.001	0	0	0	0	0	0	0	0	1	.006
Total	778	…	256	…	440	…	284	…	432	…	178a	…

^aCopy numbers of long C4, short C4, and RCCX haplotypes in SP were calculated from California SLE cohort.