Table 7. .
CNV of C4A and the TNFA −308 G→A Polymorphism in European American Female Patients with SLE and Controls
| No. (%) of |
|||||
| Factor | Female Controls | Female Patients | χ2 | P | OR (95% CI) |
| TNF2 and TNF1 | |||||
| TNF2 allele | 58 (17.0) | 100 (23.1) | 4.501 | .039 | 1.48 (1.03–2.11) |
| TNF1 allele | 284 (83.0) | 332 (76.9) | |||
| Total | 342 (100) | 432 (100) | |||
| TNF2 carriers | 53 (31.2) | 87 (40.3) | 3.41 | .07 | 1.49 (.98–2.27) |
| TNF1 only | 117 (68.8) | 129 (59.7) | |||
| Total | 170 (100) | 216 (100) | |||
| C4A GCN: | … | … | 14.5 | .0002 | 2.59 (1.57–4.28) |
| Low C4A (<2) | 27 (15.9) | 71 (32.9) | |||
| Medium/high C4A (⩾2) | 143 (84.1) | 145 (67.1) | |||
| Total | 170 (100) | 216 (100) | |||
| Controlling for C4A GCN: | |||||
| Low C4A (<2): | … | … | .95 | .366 | |
| TNF1 | 6 (22.2) | 10 (14.1) | |||
| TNF2 carrier | 21 (77.8) | 61 (85.9) | |||
| Total | 27 (100) | 71 (100) | |||
| Medium C4A (2): | … | … | 0 | 1.000 | |
| TNF1 | 78 (83.0) | 93 (83.0) | |||
| TNF2 carrier | 16 (17.0) | 19 (17.0) | |||
| Total | 94 (100) | 112 (100) | |||
| High C4A (>2): | … | … | 1.28 | .321 | |
| TNF1 | 33 (67.4) | 26 (78.8) | |||
| TNF2 carrier | 16 (32.7) | 7 (21.2) | |||
| Total | 49 (100) | 33 (100) | |||
| Controlling for TNFA polymorphism: | |||||
| TNF2 carrier: | … | … | 16.0 | .0003 | |
| Low C4A | 21 (39.6) | 61 (70.1) | |||
| Medium C4A | 16 (30.2) | 19 (21.8) | |||
| High C4A | 16 (30.2) | 7 (8.05) | |||
| Total | 53 (100) | 87 (100) | |||
| TNF1 only | … | … | 2.57 | .277 | |
| Low C4A | 6 (5.13) | 10 (7.75) | |||
| Medium C4A | 78 (66.7) | 93 (72.1) | |||
| High C4A | 33 (28.2) | 26 (20.2) | |||