Table 8. .
FBAT for RCCX, C4, and TNFA Haplotypes in the Ohio SLE Cohort[Note]
| Haplotype | Frequency | No. of Families | Observed Score | Expected Score | P |
| RCCX: | |||||
| S and L | .209 | 105 | 82 | 68.4 | .014 |
| S | .127 | 81 | 61 | 47.7 | .005 |
| C4: | |||||
| B1 | .129 | 82 | 61 | 48.1 | .005 |
| A6B1 | .041 | 31 | 11 | 17.1 | .03 |
| AQ0X | .164 | 98 | 75 | 62.0 | .013 |
| TNFA: | |||||
| TNF2 | .191 | 88 | 109 | 118 | .078 |
| RCCX(C4)-TNFA: | |||||
| S(C4B1)-TNF2 | .112 | 58 | 54 | 42.5 | .004 |
| LS(C4A6B1)-TNF1 | .032 | 25 | 8.5 | 14.8 | .011 |
Note.— All markers as a group—including RCCX, C4, TNFA, and RCCX(C4)-TNFA but not TNFA—were statistically significant. The individual haplotypes in each marker group were then tested and are summarized above. AQ0X represents bimodular RCCX structure with a mutant C4A gene with a 2-bp insertion in exon 29 (C4AQ0) and a functional C4B gene that can code for a C4B1 or C4B2 protein.