Figure 8.

Cooperation between scavenger receptors and CD36 mediates microglial release of ROS. Diagram summarizing proposed effects of CD36 on ROS production by microglia adherent to surfaces coated with Aβ fibrils. SR-A and other scavenger receptors mediate microglial adhesion to fAβ-coated surfaces. Engagement of CD36 by substrate bound fAβ signals ROS and H₂O₂ production. Pre-exposure of cells to antibodies against CD36 or the CD36 ligand TSP-1 blocks interactions between CD36 and fAβ resulting in inhibition of ROS and H₂O₂ production (see Figures 2 and 4 ▶ ▶ ).