Table 2.
Molecular Expression Profiles of Cell-Cycle Regulators in Hürthle Cell Neoplasms (n = 69) and Normal Thyroid Tissues (n = 18)
| Marker | Normal (n = 18) | Adenoma (n = 27) | UMB (n = 7) | Mi (n = 14) | Wi (n = 21) |
|---|---|---|---|---|---|
| p53 | |||||
| Negative | 18 (100%) | 25 (92.6%) | 7 (100%) | 12 (85.7%) | 15 (71.4%) |
| Positive | 0 (0%) | 2 (7.4%) | 0 (0%) | 1 (7.1%) | 4 (19%) |
| mdm-2 | |||||
| Negative | 16 (88.9%) | 5 (18.5%) | 0 (0%) | 2 (14.3%) | 5 (23.8%) |
| Positive | 1 (5.6%) | 19 (70.4%) | 5 (71.4%) | 8 (57.1%) | 12 (57.1%) |
| p21 | |||||
| Negative | 17 (94.4%) | 7 (25.9%) | 3 (42.9%) | 4 (28.6%) | 8 (38.1%) |
| Positive | 0 (0%) | 17 (63%) | 4 (57.1%) | 6 (42.9%) | 9 (42.9%) |
| Bcl-2 | |||||
| Negative | 0 (0%) | 3 (11.1%) | 2 (28.6%) | 4 (28.6%) | 5 (23.8%) |
| Positive | 18 (100%) | 21 (77.8%) | 5 (71.4%) | 6 (42.9%) | 12 (57.1%) |
| Cyclin D1 | |||||
| Negative | 18 (100%) | 25 (92.6%) | 7 (100%) | 11 (78.6%) | 17 (81.0%) |
| Positive | 0 (0%) | 1 (3.7%) | 0 (0%) | 0 (0%) | 1 (4.8%) |
Mi, minimally invasive carcinoma; Wi, widely invasive carcinoma; UMB, Hürthle cell tumor of unknown malignant behavior.
Number of patients in subgroups less than total number in respective group reflects tissue loss during tissue microarray processing.