Figure 5.

Quantitation of angiogenesis inhibition by α₁ Ab and α₂ Ab in mouse skin. Vascular cross-sectional area as a percentage of total tissue area was measured at the interface between dermis and the angiogenic stimulus (see Figure 4 ▶ , above) as described in Materials and Methods. Data are presented as the mean ± SEM. Total cross-sectional area of new blood vessels in the α₁ Ab and α₂ Ab treatment groups were each reduced ∼45% relative to controls (P < 0.001). Administration of α₁ Ab together with α₂ Ab resulted in further inhibition of neovascularization, yielding an ∼70% reduction (P < 0.001).