Figure 7.

Combined treatment with α₁ Ab plus α₂ Ab inhibits tumor growth. Administration of α₁ Ab plus α₂ Ab (closed circles) significantly (P < 0.01) inhibited intradermal tumor growth of human A431 cells, as compared with control Ab (open circles). Values represent mean values ± SEM for 10 tumors for each treatment group and time point. Note that the Abs used recognize mouse but not human integrins, and therefore Ab did not bind A431 tumor cells. Thus, effects of integrin Abs were limited to the mouse host.