Table 4.
Summary of Strain Differences in Repair Response of Bronchiolar Epithelium Following Naphthalene-Induced Acute Clara Cell Toxicity
| Day 0 | Day 1 | Day 2 | Day 4 | Day 7 | Day 14 | |
|---|---|---|---|---|---|---|
| Clara cell exfoliation | ||||||
| Swiss-Webster | Complete* | |||||
| C57BL/6 | Complete | |||||
| 129/TerSv | Complete | |||||
| 129/SvEv | Complete | |||||
| Ciliated cell squamation | ||||||
| Swiss-Webster | − | ND | ↑ | ND | − | − |
| C57BL/6 | − | ND | ↑↑ | ND | ↑ | − |
| 129/TerSv | − | ND | ↑↑↑↑ | ND | ↑↑↑↑ | − |
| 129/SvEv | − | ND | ↑↑ | ND | ↑↑ | − |
| Cell proliferation | ||||||
| Swiss-Webster | − | ↑↑ | ↑↑↑ | ↑ | ↑ | − |
| C57BL/6 | − | − | ↑↑ | ↑↑↑ | ↑↑ | − |
| 129/TerSv | − | − | ↑↑ | ↑↑ | ↑↑↑ | ↑↑ |
| 129/SvEv | − | − | ↑↑ | ↑↑↑ | ↑↑ | ↑ |
| Ciliated cell density | ||||||
| Swiss-Webster | − | ND | ↓ | ND | − | − |
| C57BL/6 | − | ND | ↑ | ND | − | − |
| 129/TerSv | − | ND | ↓↓↓ | ND | ↓↓↓ | − |
| 129/SvEv | − | ND | ↓↓↓ | ND | ↓↓↓ | − |
*, Clara cell exfoliation did not differ in the distal airways by strain.
↑ indicates degree of change from control (Day 0) for that strain; − not different from control (day 0); ND, no data at this time point.