Table 1.
Markers of Architectural Compartments in Invasive Pancreatic Cancer Tissues
| SAGE tag | Gene | Cellular function/location | Architectural compartment | SAGE tag individual values* | |||
|---|---|---|---|---|---|---|---|
| I1 | I2 | CL1 | CL2 | ||||
| tgcacttcaa | Hevin | Angioendothelial | Angioendothelial | 23 | 19 | 0 | 0 |
| aaatagatcc | Beta-catenin | Signal transduction | Epithelial | 36 | 45 | 0 | 7 |
| gttcactgca | Intercellular adhesion molecule-1 | Adhesion | Epithelial | 20 | 23 | 3 | 7 |
| tttgcacctt | Connective tissue growth factor | Growth factor | Epithelial | 33 | 19 | 3 | 0 |
| aggtcttcaa | Thrombospondin-1 | ECM component | Epithelial, Panstromal | 167 | 29 | 0 | 7 |
| gggaggggtg | MMP14 | Matrix remodeling | Epithelial | 36 | 16 | 3 | 3 |
| caggagaccc | MMP11 | Matrix remodeling | Juxtatumoral stroma | 95 | 45 | 0 | 0 |
| ggaaatgtca | MMP2 | Matrix remodeling | Panstromal, angioendothelial | 62 | 35 | 0 | 0 |
| tcttgattta | Alpha-2 macroglobulin | Secreted protein | Angioendothelial, juxtatumoral stroma | 33 | 29 | 0 | 0 |
| ctcaaccccc | Alpha-2 macroglobulin receptor | Cell-surface receptor | Epithelial, panstromal | 26 | 48 | 3 | 0 |
| tggccccagg | Apolipoprotein C-1 | Secreted lipid carrier | Juxtatumoral stroma | 78 | 42 | 10 | 3 |
| ccctaccctg | Apolipoprotein D | Secreted lipid carrier | Juxtatumoral stroma | 20 | 16 | 0 | 0 |
*Data derived from Ryu and colleagues. 1 I1, invasive pancreatic carcinoma 1; I2, invasive pancreatic carcinoma 2; CL1, pancreatic cancer cell line 1; CL2, pancreatic cancer cell line 2.