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. 2002 Mar;160(3):773–780. doi: 10.1016/S0002-9440(10)64899-7

Figure 2.

Figure 2.

Localization of Ang-1, Ang-2, and Tie-2 transcripts in human endometrium from 30 normal (A, B, D–H) and 28 menorrhagic (C) individuals. In situ hybridization was performed on endometrial tissue sections using digoxigenin-labeled antisense riboprobes for Ang-1, Ang-2, and Tie-2. A: Strong Ang-1 hybridization signal was detected in the stroma (S) and glandular epithelium (G) of early proliferative phase endometrium (magnification, ×200). B: Ang-1 was highly expressed in the stroma surrounding blood vessels (bv) in secretory phase normal endometrium (magnification, ×100). C: Weak/absent Ang-1 hybridization signal in secretory phase menorrhagic endometrium (magnification, ×100). D: No hybridization was observed on control sections hybridized with sense Ang-1 riboprobe (magnification, ×200). E: Detection of Ang-2 mRNA in the glandular epithelium and stroma in proliferative phase endometrium (magnification, ×100). F: Moderate expression of ang-2 in the stroma, glandular epithelium, and blood vessels of mid-secretory endometrium (magnification, ×200). G: Strong expression of tie-2 was present in glandular epithelium and blood vessels in late secretory (magnification, ×100) and H, mid-secretory endometrium (magnification, ×200).