Table 1.
Effect of Genotype on Number of Abnormal Muscle Fibers in 8 to 9-Month-Old Mice
| Muscle | Genotype | Mouse | Fibers/mm2 ± SD (n)* | % Abnormal | |
|---|---|---|---|---|---|
| Abnormal† | Normal | ||||
| Tibialis anterior | SJL/J | 1 | 170.0 ± 30.2 (8) | 229.0 ± 51.1 (8) | 43% |
| 2 | 108.5 ± 28.3 (8) | 343.5 ± 41.5 (8) | 24% | ||
| 3 | 252.8 ± 36.9 (6) | 142.3 ± 20.0 (6) | 64% | ||
| SJL/J B2m (−/−) | 1 | 281.2 ± 56.0 (5) | 137.7 ± 42.0 (5) | 67% | |
| 2 | 364.0 ± 87.2 (5) | 104.0 ± 18.1 (5) | 77% | ||
| Gastrocnemius/Soleus | SJL/J | 1 | 86.0 ± 29.2 (8) | 359.0 ± 30.1 (8) | 19% |
| 2 | 101.0 ± 26.0 (8) | 370.6 ± 69.5 (8) | 21% | ||
| 3 | 152.0 ± 20.0 (6) | 257.5 ± 54.3 (6) | 37% | ||
| SJL/J B2m (−/−) | 1 | 119.1 ± 28.4 (9) | 313.4 ± 58.8 (9) | 28% | |
| 2 | 116.8 ± 24.4 (5) | 313.5 ± 35.4 (5) | 27% | ||
| Quadriceps | SJL/J | 1 | 216.5 ± 63.3 (8) | 228.0 ± 28.3 (8) | 49% |
| 2 | 249.5 ± 50.9 (8) | 238.5 ± 41.5 (8) | 51% | ||
| 3 | 172.7 ± 46.4 (10) | 228.3 ± 63.3 (10) | 43% | ||
| SJL/J B2m (−/−) | 1 | 181.6 ± 57.6 (9) | 259.2 ± 118.5 (9) | 41% | |
| 2 | 296.0 ± 15.2 (5) | 156.0 ± 93.3 (5) | 65% | ||
*Number of sections examined.
†Criteria for distinguishing abnormal from normal fibers are listed in Materials and Methods.