Table 2.
The 52 Statistically Significant (P Value < 0.05) Down-Regulated Clones with the Lowest Aorta/Mesenchyme Mean Ratios (>1.5-fold) Are Listed
| Function/Title | Gene | IMAGE _ID | GenBank _ID | UniGene _ID | fold | P value |
|---|---|---|---|---|---|---|
| Growth factors, growth factor receptors, and related proteins | ||||||
| Macrophage migration inhibitory factor | Mif | 634910 | 4058276 | Mm.2326 | 1.8 | 0.030 |
| Protein tyrosine phosphatase, receptor type, K | Ptprk | 537504 | 5599548 | Mm.27856 | 1.7 | 0.009 |
| Fibroblast growth factor receptor 4 | Fgfr4 | 406823 | 5599876 | Mm.4912 | 1.6 | 0.045 |
| ECM/basement membrane | ||||||
| Matrilin 2 | Matn2 | 421018 | 1541346 | Mm.3511 | 2.3 | 0.020 |
| Plasma membrane | ||||||
| CD28 antigen | Cd28 | 576501 | 4199559 | Mm.1060 | 1.7 | 0.036 |
| Intracellular signaling and GTPases | ||||||
| Transducin-like enhancer of split 1 | Tle1 | 480907 | 4198916 | Mm.12823 | 1.7 | 0.047 |
| DNA replication/cell cycle control | ||||||
| Catalytic subunit of DNA polymerase zeta RAD54 like | Rev3l | 618141 | 5599506 | Mm.2167 | 1.7 | 0.013 |
| Cyclin D1 | Ccnd1 | 374778 | 5600017 | Mm.22288 | 1.6 | 0.007 |
| DNA binding/transkription factors | ||||||
| Grainyhead | 2.8 | 0.001 | ||||
| Balb/c zinc finger protein PZF (Pzf) | 583631 | 4442680 | Mm.140246 | 2.1 | 0.004 | |
| Myeloid/lymphoid or mixed-lineage leukemia | Mll | 481236 | 4198926 | Mm.2389 | 2.0 | 0.000 |
| MutS homolog 3 (E. coli) | Msh3 | 596177 | 4442761 | Mm.116254 | 2.0 | 0.041 |
| ELAV-like 1 (Hu antigen R) | Elavl1 | 634761 | 4058259 | Mm.21766 | 2.0 | 0.019 |
| Phospholipase c neighboring | Png | 596071 | 4442757 | Mm.140 | 1.8 | 0.009 |
| Homeo box B5 | Hoxb5 | 421728 | 5599895 | Mm.207 | 1.7 | 0.002 |
| Zinc finger protein 62 | Zfp62 | 598234 | 4442832 | Mm.16650 | 1.6 | 0.025 |
| Nuclear transcription factor-Y beta | Nfyb | 574429 | 4058033 | Mm.3259 | 1.5 | 0.020 |
| Phosphatases/kinases | ||||||
| Protein kinase C, delta | Pkcd | 421002 | 5599890 | Mm.2314 | 2.2 | 0.014 |
| Cytoskeleton | ||||||
| Tropomodulin 2 | Tmod2 | 313113 | 4058326 | Mm.44216 | 2.2 | 0.003 |
| Alpha tubulin | 1.5 | 0.032 | ||||
| Clycolysis-associated proteins | ||||||
| Aldolase 3, C isoform | Aldo3 | 315564 | 1284165 | Mm.7729 | 1.9 | 0.028 |
| Enolase 3, beta muscle | Eno3 | 608804 | 4059663 | Mm.29994 | 1.9 | 0.029 |
| Lipid methabolism | ||||||
| Lipoprotein lipase | Lpl | 475661 | 4061216 | Mm.1514 | 2.0 | 0.000 |
| Proteasome-associated proteins | ||||||
| 26S proteasome-associated pad1 homolog | Poh1-pending | 577545 | 5598782 | Mm.27933 | 1.6 | 0.012 |
| Proteasome subunit, alpha type 3 | Psma3 | 534386 | 4199760 | Mm.1007 | 1.5 | 0.012 |
| Peroxisome organization and biogenesis | ||||||
| Solute carrier family 25, member 17 | Slc25a17 | 439854 | 5597964 | Mm.306 | 1.7 | 0.032 |
| Others | ||||||
| RIKEN cDNA 0610025I19 gene | 0610025I19Rik | 317849 | 4058377 | Mm.27395 | 3.2 | 0.004 |
| ESTs | 540165 | 1681385 | 2.5 | 0.006656 | ||
| RIKEN cDNA 1110014J22 gene | 1110014J22Rik | 571623 | 1660309 | Mm.7165 | 2.4 | 0.004 |
| Monocyte macrophage 19 | Mmrp19-pending | 477887 | 4061333 | Mm.24772 | 2.4 | 0.003 |
| Na/taurocholate cotransporting polypeptide 1 | 574262 | 4061747 | Mm.150060 | 2.3 | 0.008 | |
| ESTs | 484183 | 5599581 | Mm.19962 | 2.3 | 0.047 | |
| ESTs | 401495 | 5599184 | 2.1 | 0.008 | ||
| Glycine C-acetyltransferase | Gcat | 315143 | 1283258 | Mm.18618 | 2.0 | 0.035 |
| ESTs | 315392 | 2.0 | 0.010 | |||
| RIKEN cDNA 2310012M18 gene | 2310012M18Rik | 493198 | 4057932 | Mm.41438 | 2.0 | 0.019 |
| RIKEN cDNA 2810409H07 gene | 2810409H07Rik | 538110 | 5598378 | Mm.22661 | 2.0 | 0.005 |
| Dihydrofolate reductase | Dhfr | 439059 | 5599936 | Mm.23695 | 1.9 | 0.005 |
| FK506 binding protein 4 (59 kDa) | Fkbp4 | 423657 | 1428339 | Mm.12758 | 1.8 | 0.008 |
| ESTs | 368147 | 5599080 | 1.8 | 0.013 | ||
| RIKEN cDNA 1110033B05 gene | 1110033B05Rik | 407499 | 5599230 | Mm.29145 | 1.8 | 0.007 |
| ESTs | 423973 | 1542767 | 1.8 | 0.015237 | ||
| ESTs | 476368 | 4061239 | Mm.198722 | 1.8 | 0.001 | |
| Tousled-like kinase 2 (Arabidopsis) | Tlk2 | 577746 | 4536798 | Mm.4557 | 1.7 | 0.050 |
| RIKEN cDNA 1110003P10 gene | 1110003P10Rik | 475796 | 5597998 | Mm.29051 | 1.6 | 0.048 |
| ESTs | 458629 | 1.62 | 0.033167 | |||
| Nuclear autoantigenic sperm protein | Nasp | 541012 | 5598444 | Mm.7516 | 1.6 | 0.016 |
| ESTs | 315292 | 5599793 | 1.6 | 0.002 | ||
| ESTs | 424470 | 1428236 | 1.59 | 0.001217 | ||
| ESTs | 423941 | 1407303 | 1.59 | 0.003214 | ||
| Aldo-keto reductase family 1 | Akr1b1 | 604252 | 1724211 | Mm.451 | 1.6 | 0.028 |
| RIKEN cDNA 1300007E16 gene | 1300007E16Rik | 574092 | 4058026 | Mm.183025 | 1.6 | 0.003 |
| RIKEN cDNA 2810416I22 gene | 2810416I22Rik | 332501 | 1282628 | Mm.12553 | 1.5 | 0.032 |
The genes are sorted according to function/cellular process (www.geneontology.org). No evident vascular, smooth muscle, or basement membrane markers were found. Significant clones from the nonsequenced set are not listed.