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. 2002 Mar;160(3):1115–1127. doi: 10.1016/S0002-9440(10)64932-2

Figure 5.

Figure 5.

Expression of cytochrome P4502f2 in terminal airways of tolerant mice. 6-μm paraffin sections were probed with rabbit α cytochrome P4502f2 antibody (1:10,000). In Clara cells of the terminal airways P4502f2 expression is confined to the epithelium of the airways in control mice (A). P4502f2 positive had exfoliated from the terminal airways 12 hours after a single exposure (B). After 24 hours the most terminal airways were devoid (→) of P4502f2 positive cells (C). After 2 repeated exposures P4502f2 expression remained low in the terminal airways (D). Mice administered 4 repeated injections had multifocal expression of P4502f2 (E), which after 7 repeated exposures had become a diffuse signal throughout most Clara cells (F). Mice receiving 14 (G), and 21 (H) repeated injections had P4502f2 expression which was comparable to control mice. Scale bar in A, 30 μm.