Figure 3.

Schematic representation of IgM- and IgG-derived sequences from FL. no 8-‘83 (upper part and lower part, respectively) and its relapse 8-‘92 (bottom line). Only mutations that differ from the IgM consensus sequence, as determined on crude tissue, 13 are shown. The numbers represent the different follicles from which samples were taken, as indicated in Figure 2 ▶ . Different samples from one follicle are designated with a different letter. Replacement and silent mutations are represented as closed and open circles, respectively. Codon numbers are indicated underneath the symbols. Whereas in the consensus sequence at position 81 a mutation was present as compared to the germ-line gene, the gray symbols at this site in sequence 8aγ and 4aγ represent the germ-line nucleotide.