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. 2002 Mar;160(3):953–962. doi: 10.1016/s0002-9440(10)64917-6

Figure 2.

Figure 2.

Alterations in the APC/β-catenin pathway in ACCs. A: DNA sequencing from case A13, showing an ACC (threonine) → ATC (isoleucine) mutation at codon 41 of the β-catenin gene. Sequencing of nonneoplastic tissue from this patient shows only wild-type β-catenin, confirming the somatic nature of the β-catenin mutation. B: Frameshift APC mutations in cases A16 and A18. DNA sequencing shows a 1-bp insertion A into a 6 base poly(A) tract spanning codons 1554 to 1556 in each case. The corresponding wild-type APC sequence from a different ACC is shown above. C: Nonsense APC mutation in case A2. DNA sequencing shows a CAA (glycine) → TAA (stop) mutation at codon 1444 that is present in the ACC but not in the nonneoplastic tissue from this patient.