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. 2002 Mar;160(3):917–926. doi: 10.1016/S0002-9440(10)64914-0

Figure 1.

Figure 1.

CIA development in u-PA−/− mice and control u-PA+/+ mice. A: Severity. Results are expressed as the mean clinical score ± SEM. There is significantly milder disease in the u-PA−/− mice (n = 39) compared with the u-PA+/+ mice (n = 31) (P = 0.03, Mann-Whitney using the mean clinical score of individual mice averaged throughout days 21 to 60). B: The number (%) of individual limbs with a particular clinical score is presented. For u-PA−/− mice, there are significantly less limbs with clinical scores of 2 or 3 compared with u-PA+/+ mice (P < 0.001, multi-way chi-square). C: Paw thickness for individual limbs with a particular clinical score, expressed as the mean thickness ± SEM. For u-PA+/+ mice, there is a highly significant correlation between the paw thickness and clinical score of individual limbs (r = 0.846, P < 0.001). For u-PA−/− mice, there is a weak, but significant, correlation between the paw thickness and clinical score of individual limbs (r = 0.475, P = 0.002). *, P = 0.027, paws from u-PA−/− mice with a clinical score of 3 are significantly less swollen than paws from u-PA+/+ mice with a clinical score of 3.