Table 1.

Comparison of CIA in Wild-Type and Gene-Deficient Mice

	C57BL/6	u-PA+/+	u-PA−/−	t-PA+/+	t-PA−/−
Incidence (%)*	24/33 (73)	25/31 (81)	24/39 (62)	15/22 (68)	18/19 (95)§
Median (range)†	3 (1–12)	3 (1–12)	2 (1–6)	3 (1–12)	9 (1–12)‡
Mean clinical score (day 60)	2.7± 0.7	2.7± 0.7	1.0± 0.3¶	2.9± 0.8	6.3± 1.2‡§
Day of onset	30.2± 1.6	29.0 ± 0.9	30.4± 1.2	34.3± 2.7	30.2± 1.8‡

*Cumulative incidence.

^†Median (range) of maximum clinical scores obtained for arthritic mice.

^‡Data excludes four mice sacrificed at day 21 (see text).

^§P < 0.05, t-PA−/− versus t-PA+/+ or C57BL/6.

^¶P < 0.05, u-PA−/− versus u-PA+/+ or C57BL/6.