Table 1.
Quantitation of Lead-Induced Inclusion Body Formation in Kidney From WT Mice
| Mouse strain | Lead dose (ppm, p.o.) | |||
|---|---|---|---|---|
| 0 | 1000 | 2000 | 4000 | |
| WT | N.D. | 10± 1 | 16± 1 | 21± 1 |
| MT-null | N.D. | N.D. | N.D. | N.D. |
WT and MT-null mice were given lead p.o. at 0, 1000, 2000, or 4000 ppm for 10 weeks and renal inclusion body formation was assessed. In each case 200 nuclei selected from random fields of the inner cortex of lead-treated and control sections of kidneys were scored. Data are given as the mean ± SEM (n = 3).
N.D., not detected.