Table 2.
Lead Accumulation in Kidney from WT and MT-Null Mice (μg/g Wet Weight)
| Mouse strain | Lead dose (ppm, p.o.) | ||
|---|---|---|---|
| 0 | 1000 | 2000 | |
| WT | N.D. | 10.9 ± 0.3 | 14.4 ± 0.3 |
| MT-null | N.D. | 8.9 ± 0.2* | 11.0 ± 0.7* |
WT and MT-null mice were given lead p.o. at 0, 1000, or 2000 ppm for 10 weeks, renal lead levels were measured by AAS. Data given as the mean ± SEM (n = 10).
*Significant (P < 0.05) difference from appropriate dose-matched WT mice.
N.D., not detectable.