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Immunohistochemical Analysis of Hyperplastic Pituitaries
| Group | n | Intermediate lobe | Anterior Lobe | ||||
|---|---|---|---|---|---|---|---|
| ACTH | PRL | GH | TSH | LH | ACTH | ||
| p27-null | 12 | 12 | — | — | — | — | — |
| p18-null | 10 | 9 | 1 | — | — | — | — |
| αSU-null | 5 | — | — | — | 5 | 0 | 0 |
| p27/p18 | — | — | — | — | — | ||
| double-null | 5 | 5 | |||||
| p18/αSU | — | — | — | — | |||
| double-null | 9 | 4 | 9 | ||||
n = number of pituitaries immunostained in each group.
Ten wild-type pituitaries were analyzed as controls.
Hyperplastic LH nodules were identified in 2 of 6 p27 heterozygous/p18 null mouse pituitaries.
