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Immunohistochemical Analysis of Pituitary Tissues in Wild-Type and Null Mice
| Group | p27 | SKP 2 | Jab 1 | Grb 2 |
|---|---|---|---|---|
| Wild type | ++ | + | +++ | ++ |
| p27-null | 0 | ++ | +++ | ++ |
| p18-null | +++ | +++ | +++ | ++ |
| p27/p18 | ||||
| double-null | 0 | +++ | +++ | ++ |
| αSU-null | +++ | +++ | +++ | +++ |
| p18/αSU | ||||
| double-null | +++ | +++ | +++ | +++ |
Analysis of staining: 0, negative; +, rare or <5% cells positive; ++, focal or <25% cells positive; and +++, diffuse or >25% of cells positive.
Between four to five pituitaries per group were analyzed.
