Figure 2.

Inhibition of CxCR4 with AMD3100 during chronic allergic responses significantly attenuates airway hyperreactivity in allergic mice. Animals were implanted intraperitoneally with a 3-day osmotic pump that delivered 250 μg/kg/hour of AMD3100 or the saline vehicle. The cockroach allergen-sensitized mice were given two antigenic airway challenges 48 hours apart and assessed for airway hyperreactivity 24 hours after the final allergen challenge. The data represent means ± SE from six mice in each group. Control nonallergic mice treated for 3 days with Alzet pumps containing either AMD3100 or saline followed by an allergen challenge had no alteration of AHR compared to untreated control mice (airway resistance range was between 2.5 and 4.0 cmH₂O/ml/second).