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SPTs rarely harbor alterations in the genes commonly involved in ductal adenocarcinomas. A: Only wild-type K-ras sequences were present at codons 12 and 13 in all SPTs. B: Intact Dpc4 protein expression was present in all SPTs. C: Only 3 of 19 (15.9%) SPTs showed p53 protein overexpression, as in this case (S6) that contained a distinct patch of neoplastic epithelial cells with nuclear labeling.
