Table 2.
Genetic Alterations in Pancreatic Solid-Pseudopapillary Tumors
| Case | β-catenin mutation | Nuclear β-catenin, % | Nuclear cyclin D1, % | K-ras mutation | p53 accumulation | Dpc4 loss |
|---|---|---|---|---|---|---|
| S1 | G34V | >90 | 50 | Wild-type | − | Intact |
| S2 | S37F | >90 | 30 | Wild-type | − | Intact |
| S3 | D32Y | >90 | 40 | Wild-type | − | Intact |
| S4 | G34V | >90 | 50 | Wild-type | − | Intact |
| S5 | S37F | >90 | 70 | Wild-type | − | Intact |
| S6 | G34V | >90 | 10 | Wild-type | + (Patchy) | Intact |
| S7 | S33A | >90 | 20 | Wild-type | − | Intact |
| S8 | S37F | >90 | 10 | Wild-type | − | Intact |
| S9 | D32V | >90 | 10 | Wild-type | − | Intact |
| S10 | Wild-type | >90 | − | Wild-type | − | Intact |
| S11 | D32N | 20 | − | Wild-type | − | N/A |
| S12 | S37F | 30 | − | Wild-type | − | Intact |
| S13 | S37F | >90 | 15 | Wild-type | − | Intact |
| S14 | Wild-type | >90 | − | Wild-type | 40% | Intact |
| S15 | G34R | >90 | 10 | Wild-type | − | Intact |
| S16 | S37F | >90 | 30 | Wild-type | − | Intact |
| S17 | D32Y | >90 | 30 | Wild-type | − | N/A |
| S18 | D32N | >90 | − | Wild-type | − | Intact |
| S19 | D32Y | >90 | 10 | Wild-type | + (Patchy) | N/A |
| S20 | G34R | N/A | N/A | Wild-type | N/A | N/A |
Locations of somatic mutations in β-catenin are shown by codon.
Nuclear β-catenin, cyclin D1, and p53 accumulation were evaluated based on the percentage of labeled tumor cell nuclei.
N/A, immunohistochemistry failed.