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Skp2 labels proliferating cells in lymphomas. Sections obtained from human lymphomas fixed in formalin were stained with anti-Skp2, anti-Ki-67, and anti-p27 mAbs. Ki-67-positive (A) and Skp2-positive (B) cells reside in the proliferating centers of CLL/SLL, which are mainly p27-negative (C). In DLCL, Ki-67 labeled the majority of large cells (D) in contrast to Skp2 that stained only a fraction (E). The p27-positive cells (F) were almost exclusively limited to small lymphocytes.
