Skip to main content
. 2002 Sep;161(3):1087–1097. doi: 10.1016/S0002-9440(10)64269-1

Table 3.

Morphologic Criteria to Distinguish ErbB/Ras from Wnt Pathway Tumors

Criterion ErbB/Ras pathway Wnt pathway
Histological pattern Solid Branched ductules/acinar component
Keratinization Rarely present Frequently present
Myoepithelium Not present Frequently present;*
Stroma Scanty Dense
Inflammatory infiltrates Present only in necrosis Frequently present

While myoepithelial spindle cell tumors and adenomyoepitheliomas represent only 15% of the Wnt pathway tumors, a basal myoepithelial layer is observed in more than 50% of the Wnt pathway tumors.